원문정보
Effects of Lavender (Lavandular officinalis ) Essential Oil on the Production of IFN-gamma
초록
영어
Lavander officinalis has been commonly used to produce lavender essential oil. Although the essential oil has been variously used for treating burns and soothing skin irritations and inflammation, the molecular details for the oil has not been largely unknown. Here, we demonstrated that the essential oil of Lavander officinalis decreased UVB-induced inflammation by reducing interferon-gamma (IFN-gamma) production. The purpose of this study was to investigate anti-flammation effect of lavender oil in UVB-irradiated C57BL/6 mouse and CCD- 986sk cells. Lavender oil at concentration 0.01~1% was affect to the production of IFN-gamma in the CCD- 986sk cell. When UVB-irradiated CCD-986sk cells was treated lavender oil, the production of IFN-gamma was gradually reduced in a time-dependent manner. Also UVB-irradiated mice skins with lavender oil were reduced the production of IFN-gamma more than group of UVB-irradiated mice skins. The UVB-irradiated mice group were treated of every other day with lavender oil were lower the production of IFN- gamma than other groups. These results suggest that lavender oil reduce flammation in UVB-irradiated mouse skins and cells. Lavender oil might be used as a potential resource for therapy of UVB-irradiated skin damage.
목차
Ⅰ. 서론
Ⅱ. 연구재료 및 방법
1. 세포배양
2. 실험동물
3. 라벤더 오일
4. UVB 조사와 라벤더 오일 처치
5. UVB-유도 IFN-gamma의 측정
6. 단백질 함량 측정
7. 통계처리
Ⅲ. 연구결과 및 고찰
1. IFN-gamma 생성에 대한 라벤더 오일의 효과
2. UVB 조사후 IFN-gamma 생성에 관한 라벤더 오일의 효과(in vitro )
3. UVB 조사후 IFN-gamma 생성에 관한 라벤더 오일의 효과(in vivo)
Ⅳ. 결론
감사의 글
참고문헌