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연구논문

참모자반 (Sargassum fulvellum) 물 추출물의 염증 억제 활성

원문정보

Anti-inflammatory Activity of the Water Extract of Sargassum fulvellum

정다현, 김꽃봉우리, 강보경, 정슬아, 김현지, 정희예, 박시우, 안동현

피인용수 : 0(자료제공 : 네이버학술정보)

초록

영어

The anti-inflammatory effects of Sargassum fulvellum water extracts (SFWE) were investigated using lipopolysaccharide (LPS)-induced inflammatory response in this study. To examine the potential anti-inflammatory properties of SFWE, the NO, TNF-α, IL-6, IL-1β, and cell proliferation were measured. It was confirmed that the NO and TNF-α secretion were significantly suppressed when SFWE was added to LPS-stimulated RAW 264.7 cells. Moreover, the expression of IL-6 and IL-1β cytokines was suppressed by SFWE in a dose-dependent manner. Especially, IL-6 inhibition activities were over 50% at 1% of SFWE. The cytotoxicity of SFWE and the proliferation of macrophages was measured by MTT assay. As a result, there was no cytotoxicity in the macrophage proliferation treated with SFWE compared to the control. In conclusion, these results suggested that the SFWE may have significant effects on inflammatory factors and can be a potential anti-inflammatory therapeutic materials.

목차

Abstract
 1. 서론
 2. 재료 및 방법
  2.1. 실험 재료
  2.2. 추출
  2.3. 세포배양
  2.4. Nitric oxide 분비량 측정
  2.5. IL-6, TNF-α, IL-1β 분비량 측정
  2.6. 세포 독성 측정
  2.7. 통계 처리
 3. 결과 및 고찰
  3.1. RAW 264.7 세포의 NO 분비량
  3.2. RAW 264.7 세포의 IL-6 분비량
  3.3. RAW 264.7 세포의 TNF-α 분비량
  3.4. RAW 264.7 세포의 IL-1β 분비량
  3.5. 참모자반 물 추출물의 세포 독성
 4. 결론
 감사
 References

저자정보

  • 정다현 Da-Hyun Jeong. 부경대학교 식품공학과/식품연구소
  • 김꽃봉우리 Koth-Bong-Woo-Ri Kim. 부경대학교 수산과학연구소
  • 강보경 Bo-Kyeong Kang. 부경대학교 식품공학과/식품연구소
  • 정슬아 Seul-A Jung. 부경대학교 식품공학과/식품연구소
  • 김현지 Hyun-Jee Kim. 부경대학교 식품공학과/식품연구소
  • 정희예 Hee-Ye Jeong. 부경대학교 식품공학과/식품연구소
  • 박시우 Si-Woo Bark. 부경대학교 식품공학과/식품연구소
  • 안동현 Dong-Hyun Ahn. 부경대학교 식품공학과/식품연구소

참고문헌

자료제공 : 네이버학술정보

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