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모노콜정에 대한 콩커정의 생물학적 동등성 평가

원문정보

Bioequivalence of Bisoprolol Tablet(Bisoprolol hemifumarate 5 mg)

고인자, 지상철

피인용수 : 0(자료제공 : 네이버학술정보)

초록

영어

Bisoprolol, one of the antagonist, has been used for the treatment of mild to moderate essential hypertension anti stable angina pectoris. The oral bloavailability of bisoprolo1 is high and the drug has a long elimination half-life, , which allows once-daily administration. The bioequivalence of two bisoprolol preparations was evaluated according to the guidelines of Korea Food & Drug Administration (KFDA). The test product was Concor made by Newgenpharm and the reference product was Monocor made by Wyeth Korea. Twenty healthy male subjects, 23.8 (21-30) years old and 03.8(52-92) kg, were randomly divided into two groups and a randomized cross-over study was employed. After two tablets containing 10 mg bisoprolol hemifumarate were orally administered, blood was taken at predetermined time intervals and the concentration of bisoprolol in plasma was determined using an HPLC method with fluorescence detector. Two pharmacokinetic parameters, were calculated and analyzed statistical]y for the evaluation of bioequivalence of the two products. Analysis of variance was carried out using logarithmically transformed parameter values. The confidence intervals of were log These values were within the acceptable bioequivalence intervals of log . Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating that Concor tablet is bioequivalent to Monocor tablet.

저자정보

  • 고인자
  • 지상철

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자료제공 : 네이버학술정보

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