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PP-24

Chitooligosaccharide enhances delivery of photosensitizer to tumor cells

초록

영어

Chitooligosaccharide (COS) is derived from chitosan and has low molecular weight. Since chitosan is only soluble in acidic water, COS has advantages such as excellent solubility in deionized water, ease of chemical modification, altered functionality and enhanced bioactivity. Especially, COS is regarded to have enhanced anti-carcinogenecity, anti-microbial activity, and, especially, enhanced mucosal delivery of bioactive agents. In this study, we prepared photosensitizer-incorporated COS nanoparticles through ion complex formation between COS and photosensitizer, Ce6. Since COS has cationic properties, ion complexes can be formed with anionic drug, DNA and photosensitizer. Photosentizer-incorporated COS (ChitoCe6) has small particle sizes less than 100 nm at TEM observation and particle size measurement. They enhances Ce6 delivery to HCT116 human colon carcinoma cells rather than Ce6 itself. Furthermore, Ce6-incorporated COS nanoparticles generated ROS higher than Ce6 itself in spite of anti-oxidant properties of COS. Ce6- incorporated COS nanoparticles enhances phototoxicity against tumor cells and induced apoptosis/necrosis of tumor cells. We suggest that COS nanoparticles is simple and promising vehicles for photosensitizer delivery.

저자정보

  • Young-IL Jeong Nat. Res. & Dev. Center for Hepatobiliary Cancer, Pusan National University Yangsan Hospital
  • Chung-Wook Chung Nat. Res. & Dev. Center for Hepatobiliary Cancer, Pusan National University Yangsan Hospital
  • Hye-Myung Lee Nat. Res. & Dev. Center for Hepatobiliary Cancer, Pusan National University Yangsan Hospital
  • Do-Hyung Kim Nat. Res. & Dev. Center for Hepatobiliary Cancer, Pusan National University Yangsan Hospital
  • Tae-Won Kwak Nat. Res. & Dev. Center for Hepatobiliary Cancer, Pusan National University Yangsan Hospital
  • Cy-Hyun Kim Nat. Res. & Dev. Center for Hepatobiliary Cancer, Pusan National University Yangsan Hospital
  • Dae-Hwan Kang Nat. Res. & Dev. Center for Hepatobiliary Cancer, Pusan National University Yangsan Hospital

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