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PP-22, Session 7: Glycobiotechnology II, Chairperson: Eiji Miyoshi, Chaisiri Wongkham

X-ray Crystallographic Studies on Binding Specificity of Norovirus to Lewis Antigens

원문정보

Tomomi Kubota, Akiko Kumagai, Hiromi Ito, Sanae Furukawa, Yuichi Someya, Koji Ishii, Takaji Wakita, Naokazu Takeda, Haruko Shirato, Hisashi Narimatsu

한국당과학회 한국당과학회 학술대회 ACGG 2012 Conference 2012.10 pp.51-52
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초록

영어

Norovirus (NoV) is a major causative agent of nonbacterial acute, epidemic gastroenteritis, and often widespread in winter. Although most NoV infections are cured without serious symptoms, it could cause severe symptoms in elderlies and young children. The initial infection event is adhesion of NoV to glycans expressed in the epidermal cells of the small intestine. We have identified several NoV strains that show affinity to Le

저자정보

  • Tomomi Kubota Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568, Japan
  • Akiko Kumagai Department of Virology II, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-001, Japan
  • Hiromi Ito Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568, Japan
  • Sanae Furukawa Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568, Japan
  • Yuichi Someya Department of Virology II, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-001, Japan
  • Koji Ishii Department of Virology II, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-001, Japan
  • Takaji Wakita Department of Virology II, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-001, Japan
  • Naokazu Takeda Department of Virology II, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-001, Japan
  • Haruko Shirato Department of Virology II, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-001, Japan
  • Hisashi Narimatsu Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568, Japan

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