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PP-13, Session 7: Glycobiotechnology II, Chairperson: Eiji Miyoshi, Chaisiri Wongkham

A Potential Role of ppGalNAc-T13 in Neural Differentiation

원문정보

Yingjiao Xu, Wenjie Pang, Aidong Shan, Wei Li, Yan Zha

한국당과학회 한국당과학회 학술대회 ACGG 2012 Conference 2012.10 pp.45-45
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초록

영어

Glycosylation in the nervous system is thought to play a particularly important and dynamic role in both vertebrates and invertebrates. Mucin-type O-glycosylation is initiated by a large family of UDP- GalNAc:polypeptideα-N-acetylgalactosaminyltransferases (ppGalNAc-Ts, EC 2.4.1.41) which contains 20 members. ppGalNAc-T13 is one of the essential isoform, and has been found highly and restrictively expressed in the brain and neurons [1]. In this study, we found that the mRNA and protein expression of ppGalNAc-T13 was dramatically increasing during the all-trans retinoic acid (ATRA) induced neural differentiation of embryonic carcinoma P19 cells, mouse brain development and primary neuronal cultures. ppGalNAc-T13 was localized in axons of the neurons derived from P19 cells and the O-glycosylation level was simultaneously increased during the ATRA induced neural differentiation. Furthermore, up-regulation of ppGalNAc-T13 induced the formation of lamellipodia and a higher O-glycosylation level. These results imply that the high expression of ppGalNAc-T13 in neurons may play a regulatory role in the neural differentiation. Study to explore the roles of ppGalNAc-T13 in regulating neural differentiation is under way.

저자정보

  • Yingjiao Xu Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine (SCSB), Shanghai Jiao Tong University, Shanghai, 200240, China
  • Wenjie Pang Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine (SCSB), Shanghai Jiao Tong University, Shanghai, 200240, China
  • Aidong Shan Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine (SCSB), Shanghai Jiao Tong University, Shanghai, 200240, China
  • Wei Li Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine (SCSB), Shanghai Jiao Tong University, Shanghai, 200240, China
  • Yan Zha Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine (SCSB), Shanghai Jiao Tong University, Shanghai, 200240, China

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