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논문검색

PP-12, Session 7: Glycobiotechnology II, Chairperson: Eiji Miyoshi, Chaisiri Wongkham

A biomimetic chitosan composite with improved mechanical properties in wet conditions

원문정보

초록

영어

Chitosan is one of the most widely used structural polymers for biomedical applications because it has many favorable properties. However, one of the most critical drawbacks regarding the use of chitosan as a biomedical material is its poor mechanical properties in wet conditions. Here, we designed a method to improve the mechanical properties of chitosan in wet conditions and minimized the swelling behavior of chitosan film due to water adsorption by mimicking the sclerotization of insect cuticles and squid beaks, i.e., catechol-meditated cross-linking. The biomimetic chitosan composite film was prepared by mixing chitosan with L-3,4-dihydroxyphenylalanine (DOPA) as a catecholic cross-linker and sodium periodate as an oxidant. The catechol-meditated cross-linking provided a 7-fold enhancement in the stiffness in wet conditions compared to pure chitosan films and reduced the swelling behavior of the chitosan film. This strategy expands the possible applications for the use of chitosan composites as load-bearing biomaterials.

저자정보

  • Dongyeop X. Oh School of Environmental Science and Engineering Pohang University of Science and Technology (POSTECH), Pohang
  • Dong Soo Hwang School of Environmental Science and Engineering Pohang University of Science and Technology (POSTECH), Pohang

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