earticle

영어

Polyketides are a large class of natural products that include clinically important antibiotics, antitumor compounds, immunosuppressants, pigments and herbicides. Herboxidiene is a polyketide natural product that was found to control several important biannual weeds at relatively low application rates (<250 g/hectare) without damaging wheat. Early study indicated that the epoxide and the C-18 hydroxyl groups are important for the activity of herboxidiene. While Sakai et al., 2002 reported that herboxidiene showed antitumor activity against human tumor cell lines, Koguchi et al., 1997 reported that herboxidiene up-regulated the gene expression of low density lipoprotein receptors. The interesting biological profile of this natural product has prompted us to produce its glycosylated analogues so as to alter its activity. It is well known that bioactive natural products are often complexed with sugar moieties which are essential for activity of the compound. In this study, we carried out in vitro experiments to generate glucosyl-herboxidiene and galactosyl-herboxidiene.