earticle

영어

This experiment was carried out to prove the efficacy of Rhynchosia volubilis (RV) extract in ovariectomized rats. Forty rats were divided into 4 groups, administrated saline after sham operation(sham-op), saline after ovariectomy (control), RV 500 mg/kg after ovariectomy and 0.042 mg/kg Livial after ovariectomy (positive control). We examined the water extract of RV that is capable of affects osteoblast proliferation using MG-63 and HOS-TE85. Dual energy X-ray absorptiometry (DEXA) was used to measure the tibia bone mineral density of the ovariectomized rat and sham-op groups. Serum was collected for analysis of Ca and phosphorous. The results showed that body weight gain, Tibia BMD and BMC was significantly different among groups. These results suggest that RV has therapeutic effect on ovariectomized rats.