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Human Cell Surface Glycan Mapping using Mass Spectrometry

초록

영어

Every cell in an organism synthesizes a heterogeneous array of glycans in the form of various structures. Cell surface glycosylation may play an important role in development and may provide important new sources of markers for differentiation. However, studies regarding the glycosylation of cell surfaces are limited due to the lack of sensitive analytical methods. A mass spectrometry-based method that enables specific detection and quantitation, and acquisition of structural information has been developed. We have mapped cell surface glycans from more than 30 human cell lines including embryonic stem cells, cancer cells, and somatic cell lines. The results represent that specific surface glycomic signatures might have functional implications as well as characteristic features of a specific cell type.

저자정보

  • Hyun Joo An Graduate School of Analytical Science and Technology, ChungNam National University, Cancer Research Institute, ChungNam National University, Daejeon, South Korea
  • Mary Saunders University of California, Medical School, Sacramento, CA, USA
  • Shuai Wu Department of Chemistry, University of California, Davis, CA, USA
  • Jaehan Kim Department of Food Nutrition, ChungNam National University, Daejeon, South Korea
  • Lauren Dimapasoc Department of Chemistry, University of California, Davis, CA, USA
  • Kit S. Lam University of California, Medical School, Sacramento, CA, USA
  • Carlito B. Lebirlla Department of Chemistry, University of California, Davis, CA, USA

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