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Protein O-GlcNAcylation regulates developmental growth of Drosophila through the insulin-IGF signaling pathway

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영어

Modification of nuclear and cytosolic proteins by O-linked N-acetylglucosamine (O-GlcNAc) is ubiquitous in cells. The in vivo function of the protein O-GlcNAcylation, however, is not well understood. Here, we genetically manipulated the cellular O-GlcNAcylation level in Drosophila and found that it promotes developmental growth by enhancing insulin signaling. This alteration of growth is due to cell growth and apoptosis and not to cell proliferation, and is mediated, at least in part, through O-GlcNAcylation of Akt. These results indicate that O-GlcNAcylation is one of the crucial mechanisms involved in control of insulin signaling in normal Drosophila development.

저자정보

  • Sujin Park World Class University Program, Department of Biomedical Science, Yonsei University
  • Yeon Jung Kim Department of Biology, Yonsei University
  • Si-Hyoung Park Department of Biology, Yonsei University
  • JuYuel Baek Center for Bioactive Molecular Hybrids and Department of Chemistry, Yonsei University
  • KwanSoo Kim Center for Bioactive Molecular Hybrids and Department of Chemistry, Yonsei University
  • Jürgen Roth World Class University Program, Department of Biomedical Science, Yonsei University
  • Jin Won Cho World Class University Program, Department of Biomedical Science, Yonsei University, Department of Biology, Yonsei University
  • Kwang-Min Choe Department of Biology, Yonsei University

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