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Many plants have long been known to have medicinal effect therefore have been used as medicines especially in traditional medicines. Even today, about 75% of the world population still relies on plant, plant extracts and other tools of traditional medicines in basic health need. Because of the circumstances such as the increase of chronic disorders of endogenous nature and the severe adverse effects of modern synthetic medicines, traditional medicines herbs have began to attract worldwide attention. Herbal extracts contain substances with both low and high molecular weight. Although biologically active substances of the former compounds in medicinal herbs have been studied, they can’t account for all of the clinical effects achieved. Pharmacological activities have been observed in fractions with high molecular weights from boiled water extracts of the medicinal herbs. Among the high molecular weight substances, pectins have been shown to possess a variety of pharmacological activities such as several immune-stimulating activities, anti-metastasis activity, anti-ulcer activity, cholesterol decreasing effect and so on. Pectins are also applicable for drug delivery and as the vaccine for typhoid fever. Pharmacological activities which were observed in pectins and pectic polysaccharides seem to be dependent on the fine carbohydrate structures. Many pharmacological activities have been appeared in the ramified region (rhamnogalacturonan I), but some high molecular weight rhamnogalacturonan II also showed immuno-modulating activities such as Fc-receptor up-regulation for macrophages, NK-cell activation and cytokine production enhancing activity. Even if natural pectin had no activity, chemical and enzymatic modifications may provide useful product for health care. Present observations suggest that application of pectin on health care brings many possibilities of benefits for human being.