earticle

영어

Recently, coaxial electrospinning have gained much attention to fabricate a continuous double layer of nanofibers. Using this technology, some difficult-to-process polymer solutions could be co-electrospun to form an ultra-fine core within the shell of other polymer materials. This core/sheath nanofiber would be valuable for some specific applications, such as maintaining some agent for a certain period of time, postponing drug or growth factors release to a later stage, or achieving different degradation rates in different periods of usage. Current emphasis of research is to exploit such properties and focus on determining appropriate conditions for electrospinning various polymers for eventual applications. In our study, biodegradable core/shell non-woven mats of chitosan (CS) and poly (lactic acid) (PLA) were fabricated by coaxial electrospinning. In first case, PLA formed the core of the fibers and chitosan was deposited on the surface of the PLA fibers. High molecular weight of chitosan nanofibers were not feasible to be fabricated by single electrospinning due to highly viscous solution and its polycationic possession. However, it was found that the fabrication of CS nanofiber was facilitated by coaxial electrospinning method. The PLA/CS core/shell nanofibers can be used as antibacterial materials in fields such as active and bioactive package, in biomedical and filtration areas. In second case, CS/PLA core/shell non-woven mats were prepared in which CS acted as core and PLA acted as shell. This non-woven mats have potential in drug release application. In both case, measurement of contact angle using iodine methane and water confirmed the core/shell structure of nanofibers in which the shell completely covered the core. Furthermore, the contribution of PLA and CS in the core/shell nanofibers was evaluated by tensile test and different scanning calorimetry (DSC).