원문정보
초록
영어
The mycolyl arabinogalactan-peptidoglycan complex is one of the major polysaccharide segments of the cell wall of Mycobacterium tuberculosis and plays an essential role in the survival and pathogenicity of Mycobacterium tuberculosis. The synthesis of mAGP motifs is significant because it helps to understand their potential as antitubercular drugs as well as their biological significance as substrates for enzymes involved in the biosynthesis of mycobacterial cell wall. We previously synthesised an octaarabinofuranoside of the arabinan,1 a tetrasaccharide phosphate of the linkage region,2 and cyclic galactooligofuranosides3 from cell wall of Mycobacterium tuberculosis. In this work, the synthesis of a suitably protected fragment 1 of the subunit from the arabinogalactan of Mycobacterium tuberculosis is reported. Nine monosaccharide building blocks were assembled by stereoselective glycosylations employing 2'-carboxybenzyl glycosides and glycosyl fluorides as glycosyl donors.