earticle

영어

Gangliosides are complex glycosphingolipids that contain one or more sialic acids, the major components of cytoplasmic cell membranes. these are tought to play a role in the control of biological processes including cell surface interaction, cell differentiation and transmembrane signaling. Particularly, ganglioside GM3 is abundant in the kidney tissue. Diabetes mellitus is one of the most serious metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both, associated with long-term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessel. In this study, we demonstrated that gangliosides expression patterns on kidney of mulberry-treated to STZ-induced diabetic rats. High-performance thin-layer chromatography analysis and immunostating showed that ganglioside GM3, GM2, GM1, GD1a, GD1b and GT1b were expressed in normal rats kidney, whereas ganglioside expression were strongly reduced in the kidney of diabetic rats. In 1.0% mulberry administration to diabetic rats kidney, ganglioside GM3, GM2 and GM1 expression were not different compared to normal rats kidney, whereas the other bands were not seen. Therefore, alteration of ganglioside expression in kidney of STZ-induced diabetic rats seem to be importantly involved in the development of glomerular hypertrophy and proteinuria.