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O-GlcNAc Biology

원문정보

Jeong Gu Kang, Sang Yoon Park, Suena Ji, In Sook Jang, Su Jin Park, Hyeon Gyu Seo, Hanbyeol Kim, Eun Ah Kim, Ho Jung Seo, Yang Shin Lee, Jürgen Roth, Jin Won Cho

한국당과학회 한국당과학회 학술대회 2010년 한국당과학회 하계학술대회 2010.06 pp.51-51
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

The O-GlcNAc modification is a quite different fro m conventional glycosylation in two aspects. First, it occurs in cytoplasm and nucleus and does not in endoplasmic reticulum or Golgi apparatus. Second, this is a single sugar modification and is not a long chain oligosaccharide modification. O-GlcNAc is covalently modified on hydroxyl group of serine and threonine and usually this modification affects or competes with phosphorylation. Thus this modification might modulate many cellular events due to inhibiting or sometimes accelerating phosphorylation. O-GlcNAc transferase and O-GlcNAcase are two important enzymes for modifying proteins with O-GlcNAc. More than 800 proteins have been identified as O-GlcNAcylated proteins. Today I am going to summarize results obtained last 10 years and discuss about future aspects in O-GlcNAc biology.

저자정보

  • Jeong Gu Kang Department of Biology, Yonsei University, Seoul 120-749, Korea
  • Sang Yoon Park Department of Biology, Yonsei University, Seoul 120-749, Korea
  • Suena Ji Department of Biology, Yonsei University, Seoul 120-749, Korea
  • In Sook Jang Department of Biology, Yonsei University, Seoul 120-749, Korea
  • Su Jin Park Department of Integrated OMICS for Biomedical Sciences, World Class University Program, Yonsei University
  • Hyeon Gyu Seo Department of Biology, Yonsei University, Seoul 120-749, Korea
  • Hanbyeol Kim Department of Integrated OMICS for Biomedical Sciences, World Class University Program, Yonsei University, Seoul
  • Eun Ah Kim Department of Integrated OMICS for Biomedical Sciences, World Class University Program, Yonsei University, Seoul
  • Ho Jung Seo Department of Biology, Yonsei University, Seoul 120-749, Korea
  • Yang Shin Lee Department of Integrated OMICS for Biomedical Sciences, World Class University Program, Yonsei University, Seoul
  • Jürgen Roth Department of Integrated OMICS for Biomedical Sciences, World Class University Program, Yonsei University, Seoul
  • Jin Won Cho Department of Biology, Yonsei University, Seoul 120-749, Korea, Department of Integrated OMICS for Biomedical Sciences, World Class University Integrated OMICS for Biomedical Sciences, World Class University

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