earticle

영어

Modified nucleosides are regarded as important templates in view of being extensively utilized as biodrugs as well as biological tools. They can be developed as viral and cellular polymerase inhibitors, antimetabolites, or modulators of receptor or enzyme functions. Also after being converted into oligonucleotides, they can be used in studying genome, siRNA, micro RNA, and so on. Especially, they have been used as drugs of choice for the treatment of viral diseases such as AIDS, hepatitis B/C virus (HBV/HCV), and herpetic virus (HSV). Despite of many clinically used drugs, the first generation nucleosides suffer from many drawbacks such as appearance of drug-resistance, toxicity, and metabolic unstability. To solve these problems, we have developed the 2nd generation nucleosides in which furanose oxygen was substituted with sulfur or methylene (CH2), among which several compounds are being developed as antitumor, anti-glaucoma, and anti-inflammatory agents. Recently, we discovered the novel template as next generation nucleosides, 4'-selenonucleosides with various antiviral and antitumor activities. In this symposium, the first, second, and third generation nucleosides developed in our laboratory will be presented in detail.