원문정보
한국당과학회
한국당과학회 학술대회
4th 2009 Annual Meeting of Korean Society for Glycoscience in 2009
2009.11
pp.64-64
피인용수 : 0건 (자료제공 : 네이버학술정보)
초록
영어
The stereoselsctive construction of α-sialyl linkages still remains one of the most challenging tasks in synthetic carbohydrate chemistry. In this study, a new stereoselective α-sialylation method with sialyl pentenoates as sialyl donors has been developed employing PhSeOTf as a promoter. Especially sialylations of various acceptors with 5-N-trifluoroacetyl-sialyl pentenoate in acetonitrile were highly a-selective to provide exclusively or predominantly α-sialosides. This new method was applided to the synthesis of a disaccharide part of the glycosyl phosphatidyl inositol (GPI) anchor of the scrapie prion protein.