원문정보
초록
영어
Sialyltransferases add CMP-sialic acid to the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. Here, we focused on alpha-2,3 sialyltransferase VI (ST3GAL6) as a transporter that add sialic acid to N-glycan of glycoproteins. Our study showed that amyloid β-peptide 1-42(Aβ1-42)-induced cell death of SK-N-SH human neuroblastoma cells and SB203580, a p38 MAPK inhibitor protect against Aβ1-42 toxicity. During Aβ1-42 induced-apotosis, we found that alpha-2,3 sialyltransferase VI was decreased almost 50% by 20uM Aβ1-42 and alpha-2,3 linked sialic acid on total protein decreased. Also, cell viability was increased by SB203580 in Aβ 1-42-induced cell death for about 30%. Collectively, our findings suggest that p38 MAPK signaling pathway is related with alpha-2,3 sialyltransferase VI expression in beta-amyloid induced apoptosis.