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Poster-10

Synthesis of sialyl-vancomycin and derivatives

원문정보

Dae Hee Kim, Sun Youp Kang, Won Min Seo, Sang Hee Shim, Ji Young Yang, Jin Suk Woo, Jae Kyung Sohng

한국당과학회 한국당과학회 학술대회 2008 Eastern Asian Glycoscience Symposium 2008.11 pp.53-53
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

Vancomycin is one of the antibiotics of last resort in the treatment of life-threatening infections by Gram-positive bacteria. Vancomycin was tried to modify glycone to overcome resistance mechanism specially. Vancomycin was modified by sialydation. Vancomycin and pseudo-vancomycin were glycosylated with UDP-galactose at 4'-C of glucose to synthesize galacto-vancomycin (KSY16-80) and galacto- pseudovancomycin (KSY0703-2). The galacto-vancomycin (KSY16-80) and galacto- pseudovancomycin (KSY0703-2) were sialylated with CMP-neuraminic aicd at 3''-C of galctose to synthesize sialyl-vancomycin (KSY16-91) and sialyl-pseudovancomycin (KSY0718-7). The sialyl-vancomycin and derivatives were tested by antibiotic resistance bacteria for MIC test. The sialyl-vancomycin (KSY16-91) shows less biological activity than vancomycin but galacto-vancomycin (KSY16-80) has the same activity.

저자정보

  • Dae Hee Kim Genechem Inc.
  • Sun Youp Kang Genechem Inc.
  • Won Min Seo Genechem Inc.
  • Sang Hee Shim Genechem Inc.
  • Ji Young Yang Genechem Inc.
  • Jin Suk Woo Genechem Inc.
  • Jae Kyung Sohng Institute of Biomolecule Reconstruction (iBR), Department of Pharmaceutical Engineering, Sun Moon University

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자료제공 : 네이버학술정보

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