earticle

영어

Molecular hydrophobicity (ClogP) was used to understand the permeability and irritation of human skin by the use of natural lachrymatory compounds in plants of spontaneous land as riot control agents. 25 lachrymatory compounds from the plants of 7 families, 10 genus and 17 species were handled in this study. Also human skin permeability and irritation caused by the hydrophobicities and lachrymal evaluation factors were discussed qualitatively. In the case of molecular hydrophobicities, logP = 2.0, the chemicals exhibited better permeability to the skin. In addition, allyl isothiocyanates (C-J; 1.940) from the root, leaf and seed of a crucifer such as Wasabi, Horseradish, Radish, Rapeseed, Leaf Mustard, Black Mustard, Chinese Cabbage, Cabbage, Gingerol (M3; 2.943), Zingerone (M1; 1.071) from the root of Ginger, and Xanthoxin (Q2; 1.150) from the leaf (or seed) of Sichuan pepper (Pricklyash) were closer to the hydrophobicity. From these results, it was expected that the skin permeability and irritation caused by allyl isothiocyanates (C-J) had the highest tendency out of all the other compounds. Not only Scoville hot unit(SHU) on Capsaicin derivatives, but optimized lachrymal constants of a new concept for all chemicals have to be designed. Therefore, besides chronic and acute toxicity (Carcinogenicity & Mutagenesis) and molecular hydrophobicity, the molecular docking scores (DS) from the interactions between TRPV1 (Vanilloid receptor) as an integrator of noxious pain managing, and xenobiotic (or endogenous) chemicals would have to be included as new lachrymal evaluation factors.

한국어

분자의 소수성(ClogP)에 기초하여 시위 진압용 제제로서 자생 식물중 천연 최루성 물질의 인체피부흡수와 감작성을 이해하기 위하여, 다루어진 식물들은 7과 10속 17종으로 그들이 함유하고 있는 최루성 화합물은 모두 25종류이었으며 이들 화합물의 소수성으로부터 정성적인 피부 침투성과 감작성 및최루성 평가요소를 검토하였다. 인체피부 침투성이 양호한 logP=2.0에 가까운 화합물로는 고추냉이, 겨자무. 무, 유채, 갓, 흑겨자 및 순무 등, 십자화과 식물의 뿌리, 잎 및 씨앗에 존재하는 allyl isothiocyanateC-J; ClogP=1.940), 생강의 뿌리에 gingerol (M3; 2.943)과 zingerone (M1; 1.071) 그리고 초피나무의 줄기와 잎에 있는 xanthoxin (Q2; 1.150), 등 이었으며 피부흡수와 감작성은 allyl isothiocyanate (C-J)가 제일큰 물질로 예상되었다. 또한, Capsaicin 유도체에 관한 Scoville hot unit (SHU) 뿐 아니라, 모든 화합물에대하여 최적화된 새로운 개념의 최루성 상수가 설계되어야 하겠다. 그러므로 최루성 요소로는 급만성 독성(발암성 및 돌연변이성)과 분자 소수성(logP) 이외에 생체 이물질과 유해한 통증을 통합 관리하는 주체로서 TRPV1 (vanilloid 수용체) 사이의 상호작용에 관한 분자 도킹스코어(DS)가 새로운 최루성 평가요소로 포함되어야 할 것이다.