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Objectives: The main purpose of this study was to examine factors influencing depression of middle school students in relation to coping behavior, social support, and self-esteem. Methods: The questionnaire survey was carried out on a convenience sample of 442 middle school students. The data analysis procedure included frequency, t-test, ANOVA, Pearson correlation coefficients, and stepwise multiple regression using depression as the dependent variable. Results: The prevalence of depression was 16.7%. Multiple regression revealed that the factors such as ｢negative｣ coping(β=.29, p<.001), friend support(β=-.23, p<.001), ｢social support pursuing｣ coping(β=-.22, p<.001), school record(β=.15, p<.001), self-esteem(β=-.13, p<.01), family support(β=-.13, p<.01), ｢agressive｣ coping(β=.11, p<.01) turned out to be significant affecting factors. Forty six percent of varience in depression was explained by these factors. Conclusion: The results of this study suggest that to prevent the occurrence of depression, psychosocial aspects including emotional support should be considered when developing mental health education program for middle school students.