earticle

영어

The effect of high-intensity static magnetic field (SMF) on ethanol-loaded rat was evaluated in its metabolism. Six groups of rats were fed ethanol diets for 4 weeks everyday. Postoperatively, the rats were exposed to 0.3- tesla (3000 gauss) magnetic fields (MF) of N and S poles for 24 hours per day for 4 weeks with appropriate controls. Biochemical profile of liver and serum (GOT, GPT, triglyceride, total cholesterol, ADH) were measured and morphology of liver was examined of each groups. The activity of GPT in the N pole (p < .01) or in the S pole (p < .05) groups was significantly decreased when compared to the value of the negative and positive control rats. The concentration of triglyceride was significantly decreased in the N pole (p < .01) and the S pole (p < .01) groups when compared to the value of the negative and positive control rats. The activity of ADH in the N pole (p < .01) and the S pole (p < 0.5) groups was significantly increased compared to the value of the negative and positive control rats. The results demonstrated that the 0.3-tesla static magnetic field had statistically significant effect on improved hepatic function indices (GPT, triglyceride concentration, ADH; alcohol dehydrogenase). Histologically, moderate to severe deposition of variable sized fat vacuoles in the cytoplasm of hepatocytes were observed throughout the study in the negative control group. Whereas, in the N pole and S pole treated groups, deposition of fat vacuoles were generally milder than that of the negative control group. These results suggested that the N and S poles promoted the clearance of ethanol from the circulation and the liver by directly stimulating hepatic alcohol metabolizing enzymes, and the regeneration of ethanol-induced liver damage.

한국어

만성 에탄올 섭취로 유도된 흰쥐의 간 손상에 미치는 자석의 N극과 S극의 혈중 GPT와 GOT의 생화학적 효과와 조직 병리학적 상태를 조사하였다. 쥐에 3000가우스의 자장을 조사하였다. 만성적인 에탄올 섭취시 자석의 N 및 S극 은 GPT수치를 유의적(p < .01)으로 감소시키어 간의 손상을 경감시킴을 알 수 있었다. N 및 S극 모두 총 cholesterol에는 효과가 없었으나, triglyceride 중성지방의 축적 억제에는 N 및 S극군 모두 유의적 (p < .01)으로 감소하는 효과를 나타내어 고중성 지방증에 효과가 있었다. 알코올분해효소의 활성은 N 및 S극에서 모두 효과 (p < .01)가 높았다. 간의 조직학적 소견에서는 N 및 S군은 간 세포내 지방 축적을 억제하고, 간세포 활성에 미치는 효과가 높았다. 자석 및 자장 의 N 및 S극의 유용한 점을 응용한다면 여러 가지 질병 치료에 적용시킬 수 있을 것으로 기대된다.