원문정보
초록
영어
Water-in-oil-in-water (W/O/W) microbeads were fabricated using a simple fluidic device, where the inner water phase served as drug reservoir. Using a fluidic device with three flow channels, we could obtain uniform W/O/W microbeads with a single or multiple droplets, where the inner water, middle oil, and outer water phases were an gelatin, poly(ε-caprolactone) (PCL), and poly(vinyl alcohol) solutions, respectively. The number and size of the core droplets can be tuned by changing the flow rate of each phase in the fluidic device. To demonstrate a controlled release, hydrophilic and hydrophobic dyes were encapsulated as model drugs in the core and PCL layer, respectively. Besides drug carriers, these microstructured microbeads can be further employed for cell encapsulation and tissue engineering.