earticle

영어

We have demonstrated one-step method for the fabrication of biomimetic poly(ε-caprolactone) (PCL) fibrous matrix with gradient in bone-like calcium phosphate (TCP) content. PCL solution in chloroform containing β-tricalcium phosphate nanopowders was centrifuged to induce gradient content in TCP. The PCL/TCP dispersion was electrospun into the collector, resulting in the composite matrix with a high content of TCP at the bottom and zero content at the top in the composite matrix. The morphology and the content of TCP were examined by SEM and EDX, respectively. Cell culture on PCL and PCL/TCP fibrous matrices confirmed that osteoblast (MC3T3-E1) favored the PCL/TCP fibrous matrix in terms of proliferation and osteogenic differentiation. The PCL/TCP fibrous matrix can potentially be employed for the biomimetic application to the bone and bone-to-tendon regeneration.