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Objectives: This study was conducted to identify the factors that affect depression and its association with professional job stress, social support, and drinking behavior among skin care experts. Methods: The study subjects were 207 skin care experts in Ilsan area. A cross-sectional study with self-administered questionnaire was used to collect data. A questionnaire measuring socio-demographic and job related variables, job stress, social support and depression was used. T-test, ANOVA and multiple regression were used for analysis. Results: Job related variables, job stress, social support and depression were different in education level, job position, length of job and monthly income. The factors which affect depression were age, job stress and social support after controling other variables. Conclusion: The findings suggest that the future intervention of reducing depression among skin care experts should be carefully considered by the level of job stress and social support. Employee Assistance Programs need to be developed and provided for employees in order to reduce job stress and prevent depression.