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Objectives: The aim of this study was to analyze the effects of an intervention program for reducing alcohol intake on serum GOT, GPT, GGT, Alkaline phosphatase, bilirubin, lactate dehydrogenase levels among male workers. Method: Fifteen male workers participated in the study. The intervention program were done one on one or as a group for four weeks. The program consisted of promotion strategies, educational strategies, counseling strategies and phone-texting strategies. Educational strategies were sequential information delivered on first, alcohol absorption; second, acute and chronic harms to the body; third, the process of alcohol addiction; fourth, definition of moderate drinking; fifth, maintaining methods for drinking in moderation. Paired T-test was applied to compare differences between pre and post intervention means. Results: The mean age of respondents was 47.9, mean AUDIT score was 18.67±7.45 and mean fasting glucose level was 126.6±31.6. There were no significant differences in serum cholesterol, Triglyceride and total protein levels after the intervention program. But serum albumin level(p<0.05), GOT(p<0.01), GPT(p<0.05), Alkaline phosphatase(p<0.001), lactate dehydrogenase(p<0.05) level were significantly decreased after the intervention program. Conclusion: Four weeks of intervention program reduced company worker's serum albumin, GOT, GPT, Alkaline phosphatase, lactate dehydrogenase levels significantly.