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Purpose: The purpose of this study was to investigate the Influences of Alcoholic Use Disorder, Family cohesion and Self-esteem on Mental health among University Students. Methods: Data were collected through questionnaires from 468 students and were analyzed using descriptive statistics, t-test, ANOVA, Scheffe's test, Pearson's correlation coefficients and Stepwise multiple regression analysis with SPSS/WIN 19.0 program. Results: As defined by alcoholic use disorder, the proportion of dependent group was 3.6%, disorder group was 16.9%, and genral group was 79.5%. The levels of alcoholic use disorder depended on gender and residence type. The levels of mental health depended on gender, family income and academic achievement. The mental health was significantly correlated with family cohesion and self-esteem. The influential factors affecting mental health were self-esteem, academic achievement, gender, which explained about 44.8% of the variance. Conclusion: The results of this study indicate that nursing intervention are needed to improve mental health and alcohol use disorder and that such variables should be carefully considered in intervention for university students.