earticle

영어

Fractional precipitation is the most effective method for pre-purifying paclitaxel, which is the anticancer agent, extracted from plant cell cultures. However, the fractional precipitation process has been fundamentally problematic due to the lengthy precipitation (~3 days) that is required. An improved fractional precipitation process could considerably reduce the precipitation time by increasing the surface area available for precipitation. Three different types (spiral, round, and twisted types) of reactor with an increased surface area were developed and evaluated for the purification of paclitaxel. This improved purification process serves to minimize solvent usage and the size and complexity of the high performance liquid chromatography operation required for paclitaxel purification.