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포스터 발표 : 바이오의약 및 약물전달

Surface modified gold nanorods for thyroid cell targeting

원문정보

Yoshie ARAI, Deokho JUNG, Youngeun KWON, Wonhee JANG

한국생물공학회 한국생물공학회 학술대회 2012 춘계학술대회 및 국제심포지움 2012.04 pp.260-260
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

Gold nanoparticles (GNPs) have unique properties which are surface plasmon resonance that make functional reagents for various biomedical applications including photothermal therapy. Most GNPs are prepared using growth-directing surfactants, such as cetyltrimethylammonium bromide (CTAB), which are known to have considerable cytotoxicity. We describe an approach to remove CTAB to a non-toxic concentration by PEGylaiton or antibody conjugation. The cytotoxicity of pristine and surface-modified GNRs was measured in human cell lines derived from thyroid cells. GNRs are further modified to present monoclonal antibodies that recognize a specific surface marker, sodium-iodide transporter (NIS), for thyroid cells. NIS antibody-conjugated GNRs specifically targeted human thyroid cells in vitro. Antibody-conjugated GNRs specifically targeted human thyroid cells in vitro.

키워드

저자정보

  • Yoshie ARAI Dept. of Life Science, Dongguk University, Seoul, Korea 100-715.
  • Deokho JUNG Dept. of Biomedical Engineering, Dongguk University, Seoul, Korea 100-715.
  • Youngeun KWON Dept. of Biomedical Engineering, Dongguk University, Seoul, Korea 100-715.
  • Wonhee JANG Dept. of Biomedical Engineering, Dongguk University, Seoul, Korea 100-715.

참고문헌

자료제공 : 네이버학술정보

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