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A sulfated polysaccharide, Fucoidan has been well studied as the anti-oxidant, anti-viral, anti- tumor and anti-coagulant, etc... We have proceeded with a aim to explore this molecule as an anti-melanogenic agent. It has been found, there was a significant reduction in melanin biosynthesis in melan-a cell, while treated with fucoidan, In vitro. The results showed that the concentration up to 100 ㎍/㎖, can reduces the melanin level approximately 40+5%, without any cell toxicity. A significant decrease in expression of cellular tyrosinase was observed. Means this molecule have some down regulatory role in expression of tyrosinase enzyme. Thus elucidation of the mechanism of action must be explored, which is poorly understood. In the present study, we have tried to evaluate the effect of fucoidan on the expression of major proteins, influencing the melanin synthesis. It is well known that melanin synthesis involves a series of reaction catalyzed by specific gene products. Therefore, we have targeted the key proteins like TYR, TRP-1, TRP-2, MITF, ERK, CREB etc. These present studies are important in terms of mechanism elucidation and for design and developing a fucoidan based safer cosmetics.