earticle

영어

The potentials of medicinal plants and their miraculous properties are used for the skin health since human civilization. Intrinsic or extrinsic factors involved in the skin aging process, proceeds through MMP-1 catalyzed collagen degradation. The collagen plays a structural and functional scaffold in the extracellular matrix of skin and other tissues. The aim of the present work to screen the plant extracts of Dendropanax, Cornus, and Lycium, to search the potential inhibitor of MMP-1 expression. These plants were highly cited for their medicinal properties like anti-aging, anti-inflammatory, anti-oxidant, and immunoregulatory, etc... We extracted the plant’s active parts by various extraction procedures. The antioxidant properties of the extract were evaluated by the DPPH assay. The effect of extract on the collagen synthesis and cell viability (MTT assay) was measured to compare the inhibition in MMP-1 expression and toxicity caused, respectively. The fraction showed desirable activity was further purified by HPLC. The primitive result shows the potentials of the plant’s active compound can use as the cosmetic ingredient for minimize the aging dependent wrinkle formation.