earticle

영어

To treat hyperpigmentating diseases such as such as melasma and lentigines, a number of melanogenesis inhibitors have been screened for their effectiveness in reducing melanin but none have shown to be completely satisfactory. Pink eyed dilution protein (P-protein) is a melanogenogenic protein and plays a critical role in cellular melanogenesis. The present study is aimed to develop an alternative molecular approach using P-protein small interfering RNA (siRNA) to control melanogenesis in the melan-a melanocyte. It has been observed the both P-protien and mRNA level were significantly lowered by the siRNA treatment. P-protein siRNA also suppressed melanin synthesis without any cytotoxicity in the melan-a melanocyte cells. These results suggest that molecular approaches using siRNA targeting P-protein may a novel approach for the control of the melanogenesis in a safer way.