earticle

영어

Saururus chinensis is a traditional Korean herb for curing liver diseases. So this study was performed to investigate anti-inflammatory and anti-oxidative improving effects of Saururus chinensis fermented with Bacillus licheniformis sp. SMs-07 extract(SCFE) in the liver and sera of LPS-treated rats. SCFE, Saururus chinensis extract(SCE) and rutin were orally administered into experimental groups for 30 days, while the normal and control groups were administered with water. On day 31, rats were given 5 mg/kg of LPS(the normal group was given a vehicle). LPS-treated groups markedly increased the levels of AST and ALT in sera and MDA in the liver homogenates and mitochondrial fractions, but decreased the levels of SOD, CAT and GPx in liver homogenates and mitochondrial fractions. SCFE and SCE groups decreased AST, ALT and MDA, but they increased SOD, CAT and GPx. SCFE had better activities than SCE. It could be concluded that the fermentation played the important role in the improvement of anti-oxidation and anti-inflammation.