earticle

영어

As an alternative treatment of Diabetes Melitus, xeno-transplantation of insulin-secreting pancreatic islets has been emerged. Microencapsulation of islets is essential in order to prevent islets from attack of host immune system. However, large amount of empty capsule after microencapsulation process using alginate as a biocompatible material is produced under air-driven system, which causes enlargement of transplantation volume. In this research, empty alginate capsules and encapsulated islets were separated of viability using density-gradient solution. Also, its function and viability were confirmed to check toxicity of density-gradient solution and harmness of separation process.