earticle

영어

Recently, among marine organism, microalgae were studied as potent sources for food additive, nutraceutical or pharmaceuticals. Moreover, microalgae have been reported as valuable new sources of pharmacologically active compounds. In fact, despite of enlargement of microalgae market, the researches on the effect of microalgae are insufficient. So, the aim of this study was to investigate the protective effect of protein hydrolysate from Navicula incerta against CCl4-inducing hepatotoxicity in vitro and in vivo. As the result of serum biochemical parameters, AST (GOT) and ALT (GPT) were significantly decreased at the experimental group treated with papain hydrolysate from Navicula incerta (PHNI) and CCl4 as compared with control group. In addition in vitro results suggested effective protection against liver damage. Therefore, PHNI showed promising protective effects against CCl4-induced hepatotoxicity and suggest the possibility to be used as a functional health food material. However, further studies should be needed to analyse the specific bioactivities of protein hydrolysate from Navicula incerta.