earticle

영어

The anti-inflammatory activity of w ater and ethanol extract of Forsythia koreana flowers was investigated in vivo by using 12- Otetradecanoylphorbol- 13-acetate (TPA) induced Balb/c mice ear inflammation. The thickness of TPA induced inflammatory ear increased 0.21 mm, as compared to the thickness before treatment. The thickness of TPA induced inflammatory ears which treated with water and ethanol extract (500 μg/ear) only increased 0.10 and 0.13 mm, respectively. Treatment with water and ethanol extract (500 μg/ear) reduced water content about 27.4% and 23.1% in the TPA induced skin inflammatory ears, respectively. The anti-inflammatory effects of both water and ethanol extract treatments were significant as comparing to that of exposure of TPA. Histological analysis also demonstrated that the inflammatory response of skin inflammation was inhibited by the extracts of F. koreana.