earticle

영어

Phellinus linteus is a medicinal mushroom including many bioactive compounds, containing polysaccharides that have been reported to induce antitumor activity and to inhibit tumor metastasis and recurrence. Activated macropahges such as the phagocytic uptake and release of toxic molecules containing reactive oxygen species(ROS) and nitric oxide(NO) were investigated. To investigate whether polysaccharides from Phellinus linteus were able to stimulate the functional activation of macrophage, different celluar activities of macrophage, such as NO production, ROS generation and phagocytosis, and morphological changes were assessed. The cell lines used were macrophage-like cell, RAW 264.7 cells. In this study, we evaluated immunomodulatory potency of macrophage in immune response using polysaccharides from Phellinus linteus.