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논문검색

포스터 3분 스피치, 좌장 : 이선구 (부산대학교), 윤형돈 (영남대학교)

Floridoside suppresses pro-inflammatory responses by inhibiting MAPK signaling inactivated microglia

원문정보

MinJeong KIM, BoMi RYU, Yong-Xin LI, Se-Kwon KIM

한국생물공학회 한국생물공학회 학술대회 2012 춘계학술대회 및 국제심포지움 2012.04 pp.156-156
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

The compound isolated from Marine Red alga Laurencia undulate; Floridoside was characterized for its ability in suppressing LPS mediated activation of BV-2 cells. Floridoside significantly inhibited the productions of NO and PGE2 by inhibiting iNOS and COX-2 at their protein and gene levels. The responsible molecular signaling for these inhibitory actions was found to be through suppression of the phosphorylation of MAPK molecules. These results indicate that Floridoside inhibits LPS-induced inflammatory response via blocking of MAPK signaling pathway in BV-2 cells, thus demonstrated its in vitro anti-inflammatory potential. These results suggest that Floridoside has the potential to be further developed as therapeutic against neuro-inflammation.

키워드

저자정보

  • MinJeong KIM Dept. of Chemistry, Pukyong National University, Busan, 608-737.
  • BoMi RYU Marine Bioprocess Research Center, Pukyong National University, Busan, 608-737.
  • Yong-Xin LI Dept. of Chemistry, Pukyong National University, Busan, 608-737.
  • Se-Kwon KIM Dept. of Chemistry, Pukyong National University, Busan, 608-737.

참고문헌

자료제공 : 네이버학술정보

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