earticle

영어

Today a number of nanoparticles are manufactured for clinical and medicinal purposes through conjugating with drugs or bio-molecules such as DNA, RNA, and peptides. There are three distinct ways to deliver nanoparticles into animal and human bodies: injection, feeding, and transdermal administration. In this study, we fabricated biodegradable polymeric microneedle arrays containing nanoparticles for the efficient delivery of functional nanoparticle complexes through the skin. Nanoparticle-conjugated microneedle arrays were manufactured through three steps. First, PDMS (polydimethylsiloxane) molds for needles were casted out using silicon wafer. Second, microneedles were fabricated by curing melted agarose in the mold together with nanoparticles. Third, nanoparticles were separated and arrayed by their sizes using electrophoresis. These nanoparticle-conjugated microneedles have a great potential for an alternative method to deliver cosmetic or pharmaceutical materials into human skin locally without professional procedures and pain.