원문정보
초록
영어
Marine microalgae produce large array of metabolic products. Therefore, marine microalgae is used in different fields of application including nutraceutical, pharmaceuticals and cosmetic ingredient. However, there are less reports in use of microalgae on isolating active metabolites. So, this study has focused on investigating the apoptosis inductive effects of active compound, stigmasterol isolate from marine microalgae Navicula incerta extracts. There are several reports on anti-cancer effects of plant sterols on breast cancer and prostate cancer, but no reports on liver cancer. Thus, we investigated the apoptosis inductive effects of stigmasterol on hepatocarcinoma HepG2 cells. According to the results obtained stigmasterol induce the apoptosis on HepG2 cell by down regulating Bcl-2 and by upregulating caspase-8, 9 and FASL. In conclusion, we can suggest that the stigmasterol isolated from marine microalgae shows potent apoptosis inductive effects and could be developed as a anti-cancer therapeutic against liver cancer.