원문정보
초록
영어
Novel transdermal delivery systems were developed for improving skin penetration of natural substances. Polygonum aviculare L. (P. aviculare) extracts were selected to encapsulate in delivery system because P. aviculare extracts could be applicable to antiaging and whitening agents by in vitro biological activity assay. Liposome and polymeric micelle were developed for improving skin penetration of P.aviculare extracts. The entrapment efficiency of liposome was higher than polymeric micelle. Therefore we investigated further experiment using liposome system. Franz diffusion cell and CLSM studies showed that this system promoting skin penetration of P. aviculare extracts. In vivo studies using guinea pigs and hairless mice indicated liposome system was better than control in their effectiveness on the wrinkle and whitening improvement by promoting skin penetration of P. aviculare extracts.