earticle

영어

Programming living organisms with new biological functionalities requires coordinated recombination of heterologous genetic elements into a host cell. Several approaches have been investigated to provide logical connectivity between well-defined binding events among biomolecules and the way how the biomolecular interactions lead to programmable circuit behaviors. In this study, E. coli and S. serevisiae cells were engineered to achieve small chemical-induced gene regulation. The engineered cell undergoes programmable biological behaviors through translational control of gene expression. This study may open a new avenue to construction of synthetic cells amenable to gene regulation via riboregulatory elements.