원문정보
초록
영어
The recent advances in metabolic engineering to reprogram industrially competitive microorganisms is being accelerated by a new paradigm of integrating systems-level high throughput omics technologies with emerging synthetic biology-based strain design tools. Accurate prediction and control of physiological and metabolic characteristics of microorganisms is expected to realize the next generation of metabolic engineering. Here we present a good example of systematically engineering microorganisms efficiently producing biochemicals, taking an amino acid producing Escherichia coli as an example. We are particularly interested in integration of genome-scale metabolic model with high throughput omics data that can purposefully engineer the strain for the production of biochemicals at near industrially competitive level.