earticle

영어

The goal of “Synthetic Biology” is to synthesize whole biological system or its subsystem intentionally and designing elements such as the regulatory elements and functional gene should be necessarily predictable. To achieve the successful design or redesign of the biological systems, robustness of naturally occurring biological systems has to be relieved so that cells can be easily redesigned. Bacterial cells are generally evolved at the various levels from DNA to protein for maintaining their robustness against the changing circumstances. Therefore, general strategy to modify cellular physiology depending the robustness or flexibility of the biological systems should be required. In this study, we developed the general tools to modify the biological robustness at the various levels including translation and protein levels – “UTR Designer”, “Riboselector”, and “Allosteric Deregulator”. The potentials of the platform technology developed in this study for the application to the production of biofuels and commodity chemicals.