earticle

영어

Isomagnetophoresis can be used to discriminate subtle differences in magnetic susceptibility by using a magnetic susceptibility gradient in a microfluidic channel [1]. In isomagnetophoretic immunoassays, the magnetic nanoparticles are used as labels on microbeads in sandwich-type immunoassay, detecting the amount of bound analytes by isomagnetophoretic focusing the solid-support microbeads under the magnetic susceptibility gradient and magnetic field in a microchannel. One advantage of the method is that the dynamic range of the isomagnetophoretic immunoassay system can be adjusted by altering the magnetic susceptibility gradient. In addition, this isomagnetophoretic immunoassay system can be used to analyze the selected concentration of target analytes in detail by tuning the dynamic ranges. The proposed immunoassay can be useful to accurately quantify the concentrations of biomarkers over the whole range of analyte concentrations, based on the current status and needs of the patient [2]. In this presentation, multiplexed immunoassay results based on isomagnetophoresis as well as magnetophoresis will be addressed.