earticle

영어

A series of microfluidic based point of care technologies were developed in Dalian Lab, some of them are shown as following. 1. An array microfluidic immunoassay chip integrated with micro-valves (pumps) was developed for automatic analysis of clenbuterol and testosterone. 2. A microfluidic device integrated with microvalves and micropumps and a microfluidic compact disk (CD) chip based on one-step reciprocating flow were fabricated and applied for rapid DNA hybridization analysis. These devices were used for discrimination of single nucleotide polymorphisms and detection of 48 Dengue Virus samples, the hybridization time was shortened to 90s. 3. A droplet based processing was designed and developed for on-line SPE of DNA. Multiple reagent addition-droplet splitting units were integrated on a single chip to perform the reagent addition and waste removal processes in SPE. The hepatitis B virus (HBV)-DNA extraction from serum samples was performed and followed by chip PCR. 4. The fabrication of paper based microfluidic devices in nitrocellulose membrane by wax printing for immobilization related applications was demonstrated, clenbuterol was tested as an example. It looks close to see the possibility of commercialization.