earticle

영어

Despite recent advances in imaging techniques and molecular imaging tools, biomarkers considered appropriate for detection of cancer are severely limited to a few well known surface molecules, mainly belonging to growth factor or receptor tyrosine kinase receptors. Particularly, ever-increasing knowledge of the linkage between tumor and inflammation has yet to be translated into novel approaches to better diagnose and treat cancers. In this talk, I"ll present our recent work on developing molecules against cancer biomarkers prevalent not only in tumors but also in tumor inflamed stroma, i.e., tumor endothelium and tumor-associated macrophages. These tumor-selective moieties are then formulated to provide highest sensitivity and specificity in consideration of biological and physiological barriers.