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The purpose of this study was to determine the bath effect of the electrolyzed reduced water(ERW) with the properties of high pH, low oxidation reduction potential (ORP), and antioxidant on the skin injury induced by ultra violet (UV) irradiation. For this purpose, hairless mice were irradiated with UV-B to cause skin injury, and individually taken a bath in electrolyzed reduced water (experimental group) and tap water (control group) twice a day for 15 min during 2 days. We observed scoring of skin injury, hematological analysis and cytokines profile compared to the control group. We found that skin injury of the control group was more quickly recovered than that of the ERW group. In hematological results, the levels of neutrophils and monocytes were increased in control group compared to the normal group, and increased in ERW group than TW group. But, there is no differences in basophil. The level of IFN-r was significantly increased in ERW group than that of the TW group (p<0.05).
And the levels of IL-1 , IL-6, IL-10, IL12p70 and TNF- were showed a increasing tendency. But, thesβ α e parameters had no significance between the groups.