earticle

논문검색

원보

정상성인 한국인에서 아스트로마이신 1회 잠적 주사후 약물동태학적 평가

원문정보

Pharmacokinetics of Astromicin Following a Single Intravenous Influsion in Healthy Korean Subjects

복혜숙, 최경업, 김연화, 백경란, 송재훈

초록

영어

Astromicin is an aminoglycoside antiviotic that is structually different from conventional aminoglycosides. Astromicin has been shown to be active against aerobic Gram-negative bacilli. The pharmacokinetics of astromicin were determined in 12 healthy volunteers ( of body weight) following a 30-min continuous intravenous infusion at a dose of 200 mg. The plasma and urine samples were collected up to 24 h and drug concentrations were measured by a bioassay using Bacillus subtilis. Pharmacokinetic parameters were calculated by fitting individual concentration-time curve to a one-exponential decay model. The plasma levels were at 0 h and 8 h after the infusion, respectively. The elimination half-life of astromicin was The volume of distribution was , and the total body clearance was . These pharmacokinetic parameters were similar to these of gentamicin, tobramycin, and amikacin. Therefore, it is recommended that therapeutic drug monitoring of astromicin could be conducted in a similar fashion as the other aminoglycosides.

저자정보

  • 복혜숙
  • 최경업
  • 김연화
  • 백경란
  • 송재훈

참고문헌

자료제공 : 네이버학술정보

    ※ 기관로그인 시 무료 이용이 가능합니다.
    ※ 학술발표대회집, 워크숍 자료집 중 4페이지 이내 논문은 '요약'만 제공되는 경우가 있으니, 구매 전에 간행물명, 페이지 수 확인 부탁 드립니다.

    • 4,000원

    0개의 논문이 장바구니에 담겼습니다.